El Chapo and his men find the perfect place to build the world's largest drug lab. Don Sol gives Franco money and demands that he stay away from him, but he rejects it.
Don Sol agrees to marry Berta to fulfill his political goals. Men of El Chapo confess to the US police that he was about to put a bomb in the embassy.
El Chapo sends Elba to live in another house so no one will hurt her. Don Sol and El Chapo make an agreement to make the police believe that he is trying to catch him and that both can fulfill their plans.
Isidoro leaves a message for El Chapo demanding him to defend his place, since he is determined to be his worst enemy. Elba tells El Chapo that she is expecting twins.
El Chapo asks his men to do social work on behalf of Esteban Prieto so that people vote for him. Esteban wins the elections and Don Sol is appointed Secretary of Governance.
Gov. Jorge del Toro is linked to the Sinaloa Cartel and the DEA puts pressure on Esteban Prieto and Don Sol to capture El Chapo.
Joaquín Guzmán Loera receives a visit from his second wife Graciela in Puente Grande. After Amado’s death, Benjamín and Ramón Avendaño become the new drug-trafficking lords.
After escaping the Puente Grande Penitentiary, Joaquín Guzmán Loera asks ‘Chito’ to turn himself in to the police and declare that only he helped him break out in a laundry cart. 'El Chapo' and 'Don Sol' agree to finish off the Avendaño Brothers.